Expression and function of TrkB variants in developing sensory neurons.
نویسندگان
چکیده
منابع مشابه
Developing inner ear sensory neurons require TrkB and TrkC receptors for innervation of their peripheral targets.
The trkB and trkC genes are expressed during the formation of the vestibular and auditory system. To elucidate the function of trkB and trkC during this process, we have analysed mice carrying a germline mutation in the tyrosine kinase catalytic domain of these genes. Neuroanatomical analysis of homozygous mutant mice revealed neuronal deficiencies in the vestibular and cochlear ganglia. In trk...
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15 صفحه اولCharacterization of Neurotrophin and Trk Receptor Functions in Developing Sensory Ganglia Direct NT-3 Activation of TrkB Neurons In Vivo
Spinal sensory ganglia have been shown to contain neuronal subpopulations with different functions and neurotrophin dependencies. Neurotrophins act, in large part, through Trk receptor tyrosine kinases: nerve growth factor (NGF) via TrkA, brain-derived neurotrophic factor (BDNF) and neurotrophin-4/5 (NT-4/5) via TrkB, and neurotrophin-3 (NT-3) via TrkC. In the present paper, we use antibodies t...
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The neurotrophin brain-derived neurotrophic factor (BDNF), via activation of its receptor, tyrosine receptor kinase B (trkB), regulates a wide variety of cellular processes in the nervous system, including neuron survival and synaptic plasticity. Although the expression of BDNF is known to be Ca -dependent, the regulation of trkB expression has not been extensively studied. Here we report that ...
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The neurotrophin brain-derived neurotrophic factor (BDNF), via activation of its receptor, tyrosine receptor kinase B (trkB), regulates a wide variety of cellular processes in the nervous system, including neuron survival and synaptic plasticity. Although the expression of BDNF is known to be Ca2+-dependent, the regulation of trkB expression has not been extensively studied. Here we report that...
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ژورنال
عنوان ژورنال: The EMBO Journal
سال: 1996
ISSN: 0261-4189
DOI: 10.1002/j.1460-2075.1996.tb01029.x